分子亞型 |
比率 |
IHC標記 |
細胞的組織學分級(Grade) |
增殖性基因表達 |
對化療的反應(pCR) |
預後 |
Luminal A |
50-60% |
ER+: 91-100%
PR+: 70-74%
HER2+: 8-11%
Ki67: 低 |
GI/II: 70-87%
GIII: 13-30% |
低 |
0-5% |
佳 |
Luminal B |
10-20% |
ER+: 91-100%
PR+: 41-53%
Her2+: 15-24%
Ki67: 高 |
GI/II: 38-59%
GIII: 41-62% |
高 |
10-20% |
中或差 |
Her2-enriched |
10-15% |
ER+: 29-59%
PR+: 25-30%
Her2+: 66-71%
Ki67: 高 |
GI/II: 11-45%
GIII: 55-89% |
高 |
25-40% |
差 |
Basal-like |
10-20% |
ER+: 0-19%
PR+: 6-13%
Her2+: 9-13%
Ki67: 高 |
GI/II: 7-12%
GIII: 88-93% |
高 |
≥40% |
差 |
Claudin-low |
12-14% |
ER+: 12-33%
PR+: 22-23%
Her2+: 6-22%
Ki67: 中 |
GI/II: 23-62%
GIII: 38-77% |
中/高 |
25-40% |
中或差 |
Normal breast-like |
5-10% |
ER+: 44-100%
PR+: 22-63%
Her2+: 0-13%
Ki67: 低/中 |
GI/II: 37-80%
GIII: 20-63% |
低/中 |
0-5% |
中 |
改編自P. Eroles et al. Cancer Treatment Reviews 2012; 38:698-707及JS Reis-Filho et al. Lancet 2011; 378:1812-1823.